Center of Excellence in Addiction Studies
Publications
The CEAS at the University of Arizona is composed of 8 faculty members from within the Departments of Pharmacology, Psychology and Chemistry/Biochemistry. Our investigators have broad expertise in evaluation of mechanisms that underlie the maladaptation in brain circuits relevant to pain and addiction.
2025
Dogrul, B. N., Kopruszinski, C., Dolatyari, M., Watanabe, M., Luo, S., Moreira de Souza, L. H., Vizin, R. C. L., Yue, X., Palmiter, R., Navratilova, E., & Porreca, F.. (2025). Descending facilitation from rostral ventromedial medulla mu opioid receptor-expressing neurons is necessary for maintenance of sensory and affective dimensions of chronic neuropathic pain. PAIN, 166(1). https://doi.org/10.1097/j.pain.0000000000003360 PubMed
Lee, G., Hode, V., Georgieva, T., Rau, J., Dodick, D., Schewdt, T., Neugebauer, V., Porreca, F., & Navratilova, E.. (2025). Prolactin-induced sensitization of trigeminal nociceptors promotes migraine co-morbidity in endometriosis. Cephalalgia , 45(1). https://doi.org/10.1177/03331024241313378
2024
Vizin, R. C. L., Ito, H., Kopruszinski, C., Ikegami, M., Ikegami, D., Yue, X., Navratilova, E., Moutal, A., Cowen, S., & Porreca, F.. (2024). Cortical kappa opioid receptors integrate negative affect and sleep disturbance. Translational Psychiatry, 14(417). https://doi.org/10.1038/s41398-024-03123-3
Kopruszinski, C., Lee, G., Martin, L., Barber, K., Moutal, A., Dodick, D., Navratilova, E., & Porreca, F.. (2024). A male-specific mechanism of meningeal nociceptor sensitization promoting migraine headache. Cephalalgia , 44(9). https://doi.org/10.1177/03331024241281493 PubMed
Stratton, H., Lee, G., Dolatyari, M., Ghetti, A., Cotta, T., Mitchell, S., Yue, X., Dumaire, N., Salih, L., Moutal, A., Francois-Moutal, L., Martin, L., Navratilova, E., & Porreca, F.. (ca. 2024). Nociceptors are functionally male or female: from mouse to monkey to man. Brain, 147(12). https://doi.org/10.1093/brain/awae179 PubMed Press Release
Presto, P., Kiritoshi, T., Chen, Y., Navratilova, E., Porreca, F., Neugebauer, V., & Ji, G. (2024). Chemogenetic Manipulation of Amygdala Kappa Opioid Receptor Neurons Modulates Amygdala Neuronal Activity and Neuropathic Pain Behaviors. Cells, 13(8). https://doi.org/10.3390/cells13080705 PubMed
Navratilova, E., Qu, C., Ji, G., Neugebauer, V., Guerrero, M., Rosen, H., Roberts, E., & Porreca, F.. (2024). Opposing Effects on Descending Control of Nociception by µ and κ Opioid Receptors in the Anterior Cingulate Cortex. Anesthesiology, 140(2). https://doi.org/10.1097/ALN.0000000000004773